Fig. 6: Inhibition of necroptosis in humanized mice does not compromise control of bacterial growth or dissemination | Cell Death & Differentiation

Fig. 6: Inhibition of necroptosis in humanized mice does not compromise control of bacterial growth or dissemination

From: Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

Fig. 6

a Nod scid gamma mice reconstituted with human cord blood stem cells (humanized mice) were treated with either vehicle or Nec-1s (10 mg/kg) both before and after infection with aerosolized Mtb (daily for an additional nine days post-infection) Lungs and b spleens were collected 10 days after infection, homogenized and plated on 7H11 agar plates to enumerate CFU per organ. Horizontal bars indicate the median and each point represents one mouse (n = 4 per group). There were no statistically significant differences between treatment groups (p > 0.05; t test)

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