Fig. 2
From: Mammalian endoreplication emerges to reveal a potential developmental timer
The DNA damage-differentiation response (DDDR) might link proliferation with differentiation in endoreplicating tissues. Cell cycle is hyperactivated by growth factors and cells undergo proliferation (1). Active proliferating cells accumulate DNA damage due to replication stress (RS; red nuclei; 2). The DDDR pathway is activated upon a prolonged G2/M arrest and irreparable cells undergo differentiation and endoreplication (3)
