Fig. 8 | Cell Death & Differentiation

Fig. 8

From: Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells

Fig. 8

Differential effects of miR-34a in cardiomyocytes and cardiac progenitor cells (CPCs). Cartoon image depicting differential effects of miR-34a on cell survival and proliferation in cardiomyocytes and CPCs. miR-34a reduces cell survival through inhibition of SIRT-1 and through activation of TP53 the gene encoding P53 protein. Therefore inhibition of miR-34a increases SIRT-1, but at the same time possibly increases the anti-oxidant ability of P53. In contrast, miR-34a mediated pathway may be playing a beneficial role in CPCs through ROS generation which is required for stem cells survival and proliferation. Inhibition of miR-34a reduced P53 thereby eliminating the protective effects of ROS

Back to article page