Table 1 X-linked miRNAs putatively involved in direct or indirect regulation of the PD-1/PD-L1 axis
From: Sex disparity in cancer: roles of microRNAs and related functional players
microRNA ID | X-chromosome position | Regulation | Role in cancer | 3′UTR target | Gender disparities | References |
|---|---|---|---|---|---|---|
hsa-miR-106a | chrX: 134170198-134170278 [-] | ER | Proliferation, invasion, migration and drug resistance | PD-L1; PD-L2; HIF-1; STAT3 | F>M in systemic lupus erythematosus | |
hsa-miR-18b | chrX: 134170041-134170111 [-] | ER | Proliferation, metabolism | HIF-1 | – | |
hsa-miR-19b | chrX: 134169671-134169766 [-] | ER | Proliferation, invasion, drug resistance | HIF-1 | – | |
hsa-miR-20b | chrX: 134169809-134169877 [-] | ER | Proliferation, invasion, autophagy, drug resistance | PD-L1; PD-L2; HIF-1; STAT3 | – | |
hsa-miR-221 | chrX: 45746157-45746266 [-] | ER, AR | Proliferation, migration, invasion | STAT3 | F>M in metabolic syndrome | |
hsa-miR-222 | chrX: 45747015-45747124 [-] | ER, AR | Proliferation, migration, invasion | STAT3 | F<M in whole heart or isolated cardiomyocytes | |
hsa-miR-424 | chrX: 134546614-134546711 [-] | – | Proliferation, invasion, apoptosis | PD-L1 | F>M in systemic lupus erythematosus | [57] |
hsa-miR-513 | chrX: 147213463-147213591 [-] | – | Proliferation, migration, apoptosis | PD-L1 | – | [51] |
