Fig. 3 | Cell Death & Differentiation

Fig. 3

From: LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein

Fig. 3

CASC9 promotes ESCC metastasis in vivo. a Representative images of mice from different treatment groups 8 weeks after tumor injections. Three mice from the LV-NC group presented bone and other remote metastasis. The metastatic tumors were detected under a stereoscope. Scale bars, 1 cm. b Number of metastatic nodules in lungs and other organs in mice from LV-CASC9 and LV-NC groups. c Bar chart of lung metastasis nodules in LV-CASC9 and LV-NC groups. d Representative images of lung metastases under stereoscope. Original magnification, ×1.5. Scale bars, 1 cm. e Representative images of HE and IHC staining of lung metastasis. Original magnification, ×400. Scale bars, 100 µm. f Signaling pathways of downregulated genes after CASC9 knockdown in KYSE450 cells detected by microarray analysis. g, h, i Gene expression of ECM–receptor interactions and focal adhesion pathways after CASC9 knockdown or overexpression detected by RT-qPCR. *P < 0.05, **P < 0.01, ***P < 0.001

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