Fig. 1
From: Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress
Expression of HIF controlled genes in the human retina. a, b Ct-values of housekeeping genes GAPDH, RPL28, and ACTB in the central and peripheral retina of 13 donor eyes. The central retina included the macular region whereas peripheral tissue was isolated from the mid periphery of the nasal retina. Ten nanogram cDNA were used as template. c, d Expression of HIF-regulated genes in the central and peripheral retina of 13 donor eyes relative to the expression level in a 17-year-old donor. e, f Expression of rod-specific and cone-specific genes in the central and peripheral retina of 13 donor eyes relative to the expression level in a 17-year-old donor. Expression of genes was normalized to ACTB and the housekeeping gene RPL28 served as control (c–f). Dots: individual values. Lines: linear regression through all values. Note the tendency of hypoxia-regulated genes to be expressed at higher levels and photoreceptor-specific genes to be expressed at lower levels in aged human retinas
