Fig. 6 | Cell Death & Differentiation

Fig. 6

From: The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21

Fig. 6

Effects of Ubqln4 in GC cells are mediated by p21. MKN45 cells were infected with Ubqln4 lentivirus alone or together with p21-sh2, p21-sh5, or GFP-sh lentivirus. Cells infected with empty vector lentivirus served as controls. Cells were screened in 2 μg/ml puromycin for 5 days. a MTT assay, b colony-formation assays, and c SA-β-Gal staining assays were conducted in the indicated cell lines as described in Figs. 2 and 3. Student’s t-test, **P < 0.01, ***P < 0.001

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