Fig. 4 | Cell Death & Differentiation

Fig. 4

From: The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression

Fig. 4

Co-expression of c-Jun with the HPC markers Sox9, CK-19 and Opn. a Representative double-immunofluorescence stainings for Opn (green) and Sox9 (red) (upper panel) or αSMA (red) (lower panel) of livers from mice with the indicated genotypes following 49 days of MCDD feeding. Double-positive cells are indicated by red arrows. b, c Representative immunohistochemistry of OPN (brown) and c-Jun (red) double-positive cells of mice of the indicated genotypes following 49 days of MCDD feeding (b) or liver sections of patients with NASH (c). d, e Representative immunohistochemistry of c-Jun (d = brown, e = red) and Sox9 (d = red) or CK-19 (e = brown) double-positive cells of mice of the indicated genotypes following 49 days of MCDD feeding. Double-positive hepatocytes and NPLCs are indicated by blue and red arrows, respectively. Single positive cells are indicated by black arrows. Scale bar (immunofluorescence) = 25 µm. Scale bar (immunohistochemistry) = 10 µm

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