Fig. 7 | Cell Death & Differentiation

Fig. 7

From: The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression

Fig. 7

c-Jun expression in NPLCs promotes fibrosis by regulating Opn expression. a Hepatic mRNA expression of the depicted genes following 49 days of MCDD (n = 5–13/genotype). mRNA expression is shown relative to untreated controls. b Quantification of Sirius red-stained area following 49 days of MCDD (left panel; n = 11–12/genotype) and representative stainings (right panel). c Serum ALT concentrations of mice with the indicated genotypes treated with CD or MCDD (n = 4–8/genotype and timepoint). d Quantification of Sox9-positive cells by immunohistochemistry (n = 4–10/genotype and timepoint). e Quantification of the Sirius red-positive area following 49 days of MCDD (n = 5–6/genotype). Significance was tested by Mann–Whitney test. P-values are indicated. Scale bar = 50 µm

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