Fig. 3

Macronucleophagy in disease. Multiple autophagy substrates have been identified in pathological settings. In cancer, lamin A and B (grey) as well as nucleolar components (purple) have been identified while DNA (black) when not degraded properly could cause oncogenic stress. Neurodegeneration can occur as a result of lack of functional nuclear protein clearance, nucleophagy, of PolyQ aggregates (red) or of nuclear autophagy receptor p62