Fig. 9 | Cell Death & Differentiation

Fig. 9

From: Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery

Fig. 9

Model depicting the proposed mechanism of suppression of translation initiation by circYap. In the translation initiation complex, eIF4G binds with PABP leading to mRNA circularization and bolster translation. The circYap could specifically recognize and bind with Yap mRNA, and meanwhile bind with eIF4G and PABP which are responsible for Yap translation initiation. Such bindings competitively inhibit the interaction of eIF4G and PABP and therefore suppress the translation initiation of Yap

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