Fig. 5
From: T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate
Bcl-2 antagonizes Bim to promote pre-memory cell and TCM-cell survival. a Total transferred P14-Bim-mCherry reporter cell numbers or b transferred terminal effector (Eff) or pre-memory (Pre-mem) cell numbers harvested from one spleen on 11 dpi (1 day after transfer, n = 3) or 24 dpi (14 days after transfer), with vehicle or ABT-737 treatment (n = 4). Bar graph (mean ± SD) compares the mice treated with vehicle or ABT-737 within the mice receiving Bim-mCherryhi cells or the mice receiving Bim-mCherrylo cells. Cell number fold differences and p-value are shown (unpaired two-tailed Student’s t-test). c Bar graphs (mean ± SD) show TCM-cell numbers within the mice receiving Bimhi (black bars) or Bimlo (white bars) P14 cells on 11 or 24 dpi. Cell number fold differences and p-value are shown (unpaired two-tailed Student’s t-test). d Bar graphs (mean ± SD) show Bim-mCherry MFI of transferred cells with vehicle or ABT-737 treatment. (***p < 0.001, unpaired two-tailed Student’s t-test)
