Fig. 6 | Cell Death & Differentiation

Fig. 6

From: Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling

Fig. 6

MTAs synergize with Smac mimetics to induce massive apoptosis in various human carcinoma cell lines. a A panel of human carcinoma cell lines was tested for MTAs and LCL161 co-treatment induced apoptosis. Heat map analysis of cell death index was calculated based on ATP levels. b Dose-dependent effect of NCZ (upper) or PTX (lower) treatment on HCT116 (colon cancer), MDA-MB-468 (breast cancer), and BT549 (breast cancer) cells. c Dose-dependent effect of DTX (docetaxel), VB (vinblastine), VN (vinorelbine), or VF (vinflunine) treatment on MDA-MB-468 cells in the presence or absence of 100 nM LCL161. D, DMSO; NCZ, nocodazole; PTX, paclitaxel; LCL, LCL161. Cell viability was determined by measuring ATP levels. The data are represented as mean ± SEM of duplicate wells. Results are reported from one representative experiment. Experiments were repeated independently twice (a–c)

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