Fig. 2: Met1 Ub-processing DUBs are distributed in distinct cellular localization patterns that correspond with their biological function. | Cell Death & Differentiation

Fig. 2: Met1 Ub-processing DUBs are distributed in distinct cellular localization patterns that correspond with their biological function.

From: Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond

Fig. 2

Mutually exclusive OTULIN- and CYLD-containing LUBAC complexes have been identified in different cellular locations and settings. The biological functions of these complexes depend on the DUB that interacts with LUBAC and range from the control of LUBAC auto-inhibition and activity, as well as modification of membrane- or cytosol-based substrates that control cell fate and additional processes. At present, it remains unclear (indicated by question marks) if OTULIN and CYLD are statically complexed with LUBAC or exist in dynamic equilibriums, regulated by context-type and cell-type specific determinants.

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