Fig. 4: Emerging and novel functions of OTULIN.
From: Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond
Recent data link OTULIN-mediated regulation of Met1 Ub to the control of autophagic clearance of bacteria (xenophagy) and degradation of protein aggregates. In addition, OTULIN has been implicated in the regulation of mTOR signaling in the context of liver pathologies. Furthermore, OTULIN-mediated control of Met1 ubiquitination of STAT1 has been shown to regulate IFN-mediated antiviral signaling. Finally, OTULIN interacts with SNX27 to regulate endosome-to-plasma membrane trafficking, thus revealing a novel Ub-independent cytosolic function of OTULIN.
