Fig. 2: Stimulus-induced phosphorylation regulates DUB-substrate recruitment during differentiation.
From: Deubiquitylases in developmental ubiquitin signaling and congenital diseases
Stimulus-induced phosphorylation is frequently used to regulate DUB-substrate recruitment during developmental cell-fate decisions. This can occur through interaction-promoting or -inhibiting substrate modification (upper panel). Examples in which substrate phosphorylation promotes and inhibits DUB-substrate interaction include USP15-β-catenin and USP21-NANOG, respectively. Stimulus-induced phosphorylation can also occur on DUBs to promote interactions with substrates (e.g., USP9X-ankyrin G, lower panel).
