Fig. 2: TfR2 deletion is protective in 12-week-old MPTP-treated mice. | Cell Death & Differentiation

Fig. 2: TfR2 deletion is protective in 12-week-old MPTP-treated mice.

From: Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease

Fig. 2

A TH immunoreactivity in striata of MPTP or vehicle-treated animals. TfR2 deletion mitigates striatal denervation in brains of female mice. B Unbiased stereological counts of TH immunopositive neurons in the substantia nigra confirm that TfR2 targeted deletion is protective in 12-week-old females, but not in males. C Perls’ staining for Fe3+ reveals reduced iron accumulation in the midbrain after MPTP treatment in animals with TfR2 targeted deletion (12-week-old mice). Data in experimental groups are expressed as percentage of the respective TfR2fl/flTH:Cre−/− vehicle-treated control group. Two-tailed Student’s t test; *p < 0.05, **p < 0.005, ***p < 0.001. Calibration bars: 1 mm in (A), 2 mm (left) and 100 μm (right) in (C).

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