Fig. 3: Effects of ARRB1 and ARRB2 knockout on microglia-induced DA neuron damage.
From: Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3
a–d Expression of Bcl-2, Bax and TH in DA neurons treated with CMs of WT, ARRB1 knockout or ARRB2-deficient microglia. e and f The viability of DA neurons. g–j Nuclear morphology (g–i) and Hoechst-positive DA neurons (h–j). Scale bars, 50 µm. k–n Morphology of DA neurons (k–m) and TH+ cell neurite length (l–n). Scale bars, 25 µm. Quantitative data are mean ± s.e. (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001.
