Fig. 1: Aberrant nuclear export of HP1γ is induced by high-risk HPV E6 protein.
From: HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53
a Immunohistochemical staining of HP1γ protein in cervical tissues from normal specimens (upper) and HPV-positive cervical adenocarcinoma patients (lower). b Immunoblot analysis of cytoplasmic and nuclear extracts from C33A cells expressing Flag-HPV16 E6. c Immunoblot analysis of cytoplasmic and nuclear extracts from SiHa cells expressing siRNA of HPV16 E6. d Box-and-Whisker plot of relative XPO1 expression in cervical cancer cell lines (n = 9), normal tissues (n = 24), and cervical cancer tissues (n = 28) (GDS3233). e Immunoblot analysis of HP1γ immunoprecipitates (IP) and whole-cell lysates (WCL) from C33A cells expressing Flag-HPV16 E6.
