Fig. 3: Inhibiting the nuclear export of HP1γ promotes p53 effects in cervical cancer cells.
From: HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53
a Immunoblot analysis of SiHa cells expressing doxycycline-induced HP1 WT or AA treated with or without doxycycline for 48 h. b Clonogenic assay of SiHa cells expressing doxycycline-induced HP1 WT or AA treated with or without doxycycline for 20 days. c–e In vivo tumorigenesis assay of SiHa cells was performed. SiHa cells expressing HP1 WT or AA were injected into the flank of nude mice. f Immunohistochemical staining of HP1γ protein in tumor tissues derived from mice injected with SiHa cells expressing HP1 WT or AA. Data are presented as the mean ± SD (n = 6). *P < 0.05; **P < 0.01; ***P < 0.001.
