Fig. 4: HP1 isoforms regulate UBE2L3-dependent p53 ubiquitination in cervical cancer cells.
From: HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53
a Model for UBE2L3-mediated p53 degradation upon high-risk HPV infection. b Pearson’s correlation analysis in different areas of cervical cancer tumors (GDS2416) (n = 33). c Immunoblot analysis of HeLa cells expressing siRNA of HP1 isoforms. d Immunoblot analysis of p53 immunoprecipitates (IP) and whole-cell lysates (WCL) from HeLa cells expressing siRNA of HP1 isoforms after MG-132 treatment. e The mRNA levels of TP53 in HeLa cells expressing siRNA of HP1 isoforms. f The mRNA levels of p53 target genes in HeLa cells expressing siRNA of HP1 isoforms. Data are presented as the mean ± SEM (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.
