Fig. 7: Molecular model describing p53 regulation by HP1γ-dependent UBE2L3 suppression.
From: HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53
a Upon high-risk HPV infection, the E6 oncoprotein of HPV interacts with p53 and E6AP to induce polyubiquitination and proteasomal degradation of p53. Moreover, HPV infection induces exportin-1-mediated nuclear export of HP1γ, thereby allowing plenty of UBE2L3 to be expressed, which results in p53 degradation in an HPV-specific manner. b When the NES mutant HP1γ (HP1γ AA) is overexpressed artificially in cervical cancer cells, exportin-1 fails to transport HP1γ AA to the cytoplasm and HPV-specific degradation of p53 is impaired due to UBE2L3 suppression by nuclear HP1γ.
