Fig. 8: Schematic diagram depicting the influence of USP2 and HSP90 inhibitors on cell surface ErbB2. | Cell Death & Differentiation

Fig. 8: Schematic diagram depicting the influence of USP2 and HSP90 inhibitors on cell surface ErbB2.

From: The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer

Fig. 8

a The current working model shows the regulation of cell surface ErbB2 by USP2 and HSP90. Under steady state conditions, USP2 protects ErbB2 surface levels by restricting its ubiquitylation. Through inhibiting USP2, ML364 potentiates the pro-degradation effects of HSP90 inhibitors toward ErbB2, which collectively elicit potent anti-cancer effects.

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