Table 1 Quantitative analyses of CRUs and mitochondria frequency, mitochondria intracellular disposition, and CRUs-mitochondria association.

From: Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy

 

A

B

C

D

E

 

Number of CRUs/100 μm2

Number of mitochondria/100 μm2

Mitochondrial volume/total fiber volume %

Number of mitochondria at the A band/100 μm2

Number of CRU-mitochondria pairs/100 μm2

Control

12 ± 4

51 ± 11

6.8 ± 1.8

1 ± 1

7 ± 1

SEPN1-RM1

10 ± 6

24 ± 18*

6.6 ± 3.0

7 ± 7*

1 ± 1

SEPN1-RM2

1 ± 1*

16 ± 11*

5.9 ± 2.1

12 ± 9*

0 ± 0

SEPN1-RM3

1 ± 1*

12 ± 4*

3.1 ± 1.4*

12 ± 11*

0 ± 0

  1. Data are shown as mean ± SD.
  2. *p < 0.05 for Student’s t test.
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