Fig. 4: Repeated IN delivery of MSC-CS significantly restores memory whereas MSC-CS-WT old or young has partial or no effect, respectively. | Cell Death & Differentiation

Fig. 4: Repeated IN delivery of MSC-CS significantly restores memory whereas MSC-CS-WT old or young has partial or no effect, respectively.

From: Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice

Fig. 4

a Experimental design for MSC-CS treatment. DI of the recognition memory task of mice tested 7 days after 1 (b) or 4 (c) IN administrations, or 39 days after suspension of MSC-CS treatment (d). e DI of the recognition memory task of mice tested 7 days after 4 IN administrations of MSC-CS-WT old. f DI of the recognition memory task of mice tested 7 days after 4 IN administrations of MSC-CS-WT young. Data are expressed as scatter plots with mean ± SEM. One-way ANOVA; **P < 0.01; ***P < 0.001; ****P < 0.0001, Tukey’s multiple comparison post-hoc test.

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