Fig. 5: Repeated IN delivery of MSC-CS significantly decreases brain amyloidosis.
From: Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice
a 6E10 immunostaining comparing brain plaque load between MSC-CS- and PBS-treated mice (left panels). In the middle and right panels, higher magnification of plaques in cortex (c) and hippocampus (h) showing MSC-CS-mediated changes in terms of aggregate density, and absence of the central plaque core. b, c Plaque quantification in the cortex and the hippocampus. Quantitative data are expressed as scatter plots with mean ± SEM. *P < 0.05, Student’s t test.
