Fig. 6: Repeated IN injections of MSC-CS significantly reduce neuroinflammation.
From: Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice
a, b IBA1 and GFAP immunostaining showing the extent of gliosis in the cortex and the hippocampus between PBS- and MSC-CS-treated (8 IN) 25-month-old APP/PS1 mice (upper panels). Quantification of the IBA1- and GFAP-marked areas in the cortex and the hippocampus, respectively (lower panels). c CD68 quantification in plaques. d Immunofluorescence images of plaques (6E10), CD68 and IBA1 expression, and CD68-IBA1 co-localization (Merge) around plaques between treatment groups. Quantitative data are expressed as scatter plots with mean ± SEM. ***P < 0.001; *P < 0.05, Student’s t test.
