Fig. 8: APP/PS1 mice treated repeatedly with MSC-CS display a higher number of neuronal cells in the cortex and the hippocampus, reduced hippocampal atrophy, and increased survival.
From: Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice
Left panels are representative NISSL-stained sections of the cortex (a) and cell layer thickness in the CA1 region of the hippocampus (b) and the dentate gyrus (DG) (c). Right panels show neuronal quantification thereof. d Images of NISSL-stained brain slices in which headed arrows at M1, M2 and M3 indicate where thickness was measured between the CA1 and DG hippocampal sub-regions. e Quantification of neuropil thickness for the 3 zones selected. Data are expressed as scatter plots with mean ± SEM. One-way ANOVA; *P < 0.05, **P < 0.01; ***P < 0.001, ****P < 0.0001; Tukey’s multiple comparison post-hoc test. f The graph describes mouse longevity comparison between MSC-CS-treated and PBS-treated APP/PS1 mice. The red line in APP/PS1 + MSC-CS indicates that these mice were sacrificed for experimental needs, but were still perfectly healthy. ***P < 0.001, Student’s t test.
