Fig. 5: CircRNA-vgll3 regulates bone formation in vivo. | Cell Death & Differentiation

Fig. 5: CircRNA-vgll3 regulates bone formation in vivo.

From: CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression

Fig. 5

a Fluorescence images of ADSCs on CPC scaffolds. Scale bars: 200 µm. b SEM images revealed that the transfected ADSCs were tightly adherent to the surface and pores of CPCs with a large amount of ECM fibril networks. c Micro-CT showed that new bone regeneration was promoted in the Lenti-circRNA-vgll3 group, whereas it was impaired by circRNA-vgll3 inhibitor 8 weeks post implantation. d–f Micro-CT quantitative analysis showed that the BMD, BV/TV and Tb. N of the overexpression group were markedly enhanced compared to the Lenti-NC group, whereas they were inhibited in the circRNA-vgll3 inhibitor skulls than those in the Lenti-NC skulls. *P < 0.05, statistical analysis was performed by one-way ANOVA.

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