Fig. 2: Kupffer cell CLEC4F is a dominant receptor in mediating the rapid clearance of desialylated platelets in the liver.
From: Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice

A Flow cytometry analysis of galactose exposure (RCA I binding) on platelets of either WT or Clec4fâ/â recipients treated with Arthrobacter ureafaciens-derived neuraminidase at different time points. MFI, Mean fluorescence intensity. B Percentage of platelets of either WT or Clec4fâ/â recipients treated with Arthrobacter ureafaciens-derived neuraminidase at different time points. Platelet count was measured using flow cytometric analysis of peripheral blood based on anti-CD41. C Representative immunofluorescent images showing association of platelets (CD41, red) with Kupffer cells (F4/80, blue) in the liver sections. Endothelium, (CD31, green). D, E Quantification of association of platelets with liver Kupffer cells or Kupffer cell (KC) number at 2âh after Îą neuraminidase injection. nâ=â5â10 images/10âĂâfields/experiment. Data represent meansâÂąâSEM from three experiments. *Pâ<â0.05.