Fig. 4: BCL-XL inhibition impairs adenoma outgrowth in vivo.
From: BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer
a Representative images from a colonoscopy of VillinCreERApcfl/fl mice, three weeks after being induced with a single injection of 4-hydroxytamoxifen into the colonic submucosa. ABT-199 and A-1155463 treated mice received 100 mg/kg of drug for 2 days prior to induction followed by treatment every other day until day 28. Red arrows indicate tumors. b Quantification of colonic tumor size (normalized to the size of the lumen) of mice described in (a), n = 6 for vehicle, n = 4 for ABT-199, and n = 5 for A-1155463, one-way Mann–Whitney U-test, p = 0.47 (vehicle vs ABT-199) and P = 0.02 (vehicle vs A-1155463). Data represents mean ± SD.
