Fig. 1: Cortical (c) and medullary (m) thymic epithelial cell (TEC) compartments in WT and HOIL-1 and HOIP cKO mice.
From: The quest for the “HOIL-1” grail of T-cell development
TEC-specific deletion of components of LUBAC E3 ligase complex provoke a deterioration of TEC microenvironment and significantly reduced T-cell production by the thymus. In WT TECs (left), integral LUBAC-mediated signaling induces cell survival and regulates other yet to identified pathways important for TEC biology. In cKO TECs (right), attenuated LUBAC-mediated signaling leads to apoptosis/necroptosis and deregulate other routes important for TEC biology.
