Fig. 5: sMOCS capture relevant features of the fresh tissue while preserving hallmarks of HGSOC ascites that do not emerge from 2D culture.
From: Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer
a Pathway analysis on the groups of genes and 2D culture; (b) pathway analysis on the groups of genes that correlate among fresh ascites and monoclonal 3D system; (c) heatmap of differentially expressed genes between sMOCS and 2D culture; (d) pathway analysis performed on DEGs in (c): color scale define the predicted activation/deactivation of the pathway; orange identifies the pathways activated in sMOCS; (e) IPA causal network derived from DEGs in (c): color scale define the expression of downstream regulated genes and their associated function, the orange tone identifies the genes and functions activated in sMOCS.
