Fig. 5: GPX4 promotes cancer cell proliferation and tumorigenicity in vitro and in vivo. | Cell Death & Differentiation

Fig. 5: GPX4 promotes cancer cell proliferation and tumorigenicity in vitro and in vivo.

From: EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma

Fig. 5

A CCK-8 assay of EBV-positive CNE2 (left) and HK1 (right) GPX4 knockdown cells. B Colony formation by the indicated cells (n = 3). C–E. Subcutaneous tumors formed by EBV-positive control and shGPX4 CNE2 cells in nude mice were excised 17 days after inoculation. Tumor growth was assessed by assessing volume changes over time (D) and weight at the endpoint (E) (n = 7). F Expression of GPX4 and Ki67 in the xenografts was examined by immunohistochemistry staining. G Cell death in the xenograft tumors was assessed by TUNEL staining (red). Data are shown as the mean ± SD. **p < 0.01; ***p < 0.001. A and B two-tailed unpaired t test. D and E two-tailed Mann–Whitney test. F and G scale bars: 100 µm (F) and 50 µm (G).

Back to article page