Fig. 3: Targeting type I IFN production by SARS-CoV-2.

a Schematic demonstration of the viral proteins. Those marked with asterisks were reported to regulate IFN production. b IFN production signaling pathways targeted by SARS-CoV-2 proteins. SARS-CoV-2 infection induces a delayed type-I IFN response, which is underlaid by the inhibited RIG-I/MDAS-MAVS signaling at the early stage and the cytoplasmic-micronuclei-activated cGAS-STING signaling at the late stage.