Fig. 1: UFL1 promotes antiviral innate immunity.
From: UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation
A, B Ufl1 expression in PMs infected with HSV-1 or VACV detected by qRT-PCR (A) and Western blot (B). C Ifnb1, Il6 or Tnf mRNA expression in PMs infected with HSV-1 or VACV. D IFN-β and cytokines production in supernatants of PMs 24 hr post HSV-1 infection. E Ifnb1 and Il6 mRNA expression in PMs transfected with ISD or Poly dG:dC. F IFNB1 and IL6 mRNA expression in A549 cells transfected with Poly dA:dT. G Ifnb1 and Il6 mRNA expression in PMs infected with VSV or transfected with Poly I:C. H HSV-1 titers in supernatants of PMs by TCID50 assay. I Ifnb1 mRNA and HSV-1 TK RNA expression in Irf3−/− PMs infected with HSV-1. Data are presented as means ± SD from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.
