Fig. 1: Genetic and transcriptional alterations of ARGs in PDAC.
From: Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway
A Mutation frequencies of 38 ARGs in 178 PDAC patients from the TCGA cohort. B Expression distributions of 38 ARGs between normal and PDAC tissues. C Expressions of ARGs and clinicopathologic features between clusters 1 and 2. D GSVA of biological pathways between clusters 1 and 2, in which red and blue represent activated and inhibited pathways, respectively. E, G–J. Scatter plots showing correlation of transcript expression between SIRT4 and autophagy pathway in different tumors. F Scatter plots showing correlation of transcript expression between SIRT2 and autophagy pathway in PDAC.
