Fig. 7: The SIRT4/AMPKα/p53 axis is of great clinical significance in PDAC patients. | Cell Death & Differentiation

Fig. 7: The SIRT4/AMPKα/p53 axis is of great clinical significance in PDAC patients.

From: Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway

Fig. 7

A Kaplan–Meier analysis of overall survival of PDAC patients with different expressions of SIRT4 and p53. B Representative images of IHC staining to detect the expressions of related proteins in clinical tissue samples of PDAC patients. C Statistical analysis of related protein expression levels and SIRT4 expression levels in clinical tissue samples of PDAC patients. D Schematic diagram of SIRT4-AMPK-p53 axis in regulating autophagy and PDAC development. GraphPad software was used for independence Sample t-test, (*P < 0.05; **P < 0.01; ***P < 0.001).

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