Fig. 3: Cardiac-specific overexpression of HIP-55 alleviates MI injury.
From: Adaptor protein HIP-55-mediated signalosome protects against ferroptosis in myocardial infarction
A Genotyping of WT and cardiac-specific overexpression of HIP-55 (HIP-55Tg) mice. B Western blot analysis of HIP-55 expression in the heart tissues of WT and HIP-55Tgmice. C Cardiac-specific overexpression of HIP-55 suppressed myocardial infarction size. Representative Alcian blue-TTC staining of the heart tissue obtained from the WT and HIP-55Tg mice post-MI (left). Quantification of the ratios of AAR/LV and infarct size of each group (right). WT, n = 9; HIP-55Tg, n = 11. D The ratio of heart weight to tibial length (HW/TL) in WT and HIP-55Tg mice after MI. n = 6–7. E Cardiac-specific overexpression of HIP-55 suppressed MI-induced cardiac dysfunction. Representative M-mode echocardiographic photographs (left) and cardiac contractile function (right) quantified by echocardiographic analysis of ejection fraction (EF) and fractional shortening (FS) in WT and HIP-55Tg mice at day 7 after MI. n = 5–7. *P < 0.05, **P < 0.01. All error bars represent mean ± SEM.
