Fig. 5: ER stress response element requires RNA sequences downstream of the second AUG in human p53. | Cell Death & Differentiation

Fig. 5: ER stress response element requires RNA sequences downstream of the second AUG in human p53.

From: The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Fig. 5

Left panel: cartoons depicting the design of the human-mouse hybrid p53 constructs. Right panel: Western blots showing the expression of these constructs in H1299 cells. Initiation from the 2nd AUG requires human p53 mRNA sequences extending beyond the 2nd AUG. Sequences including downstream of the 2nd AUG in the human p53 mRNA (+118 to +250 nts) are required to induce initiation at the second AUG.

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