Fig. 3: Proposed contribution of autophagy-induced chromatin modifications to transgenerational epigenetic inheritance in response to famine, i.e. nutrient starvation.
From: The hunger strikes back: an epigenetic memory for autophagy
Exposure of human to famine, i.e. nutrient deprivation, is linked to transgenerational effects on health span and longevity in their offspring. Nutrient starvation-induced autophagy is associated to modifications of the chromatin, including DNA methylation and histone posttranslational modifications (including H3K4me3, H3K9me3, H3R17me2, H3K27me3/ac, H3K56ac, H4K16ac and H4K20me3), some of which are reported to contribute to transgenerational epigenetic inheritance. Hence, an epigenetic memory of autophagy could contribute to food deprivation induced effects across successive generations. The image was created with BioRender.com.
