Table 1 Is There Evidence for Differences in the Tp53 gene in multiple myelomas of Americans of African versus European descent?.

From: Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent

Codon

African Descent

European Descent

Phenotypes

31

  

?

47

serine

proline

Impaired apoptosis, ferroptosis and increased m-TOR activity

72

proline

arginine

LFS- earlier age of onset of Cancers;

Breast cancer differences in overall survival, MDM-2-p53 binding site

107

histidine

tyrosine

Cancer survival, immune responsiveness

P53 responsive gene-PADI-4 regulates the immune response

Intronic polymorphisms

Pin2

G/C polymorphism in intron 2

RNA levels regulated

Pin 3

16 bp duplication/16 bp

Splicing variations and a G-quadraplex, RNA levels regulated

(refs: exonic, 18–22; intronic, 32, 33)

 
  1. Three exon coding region polymorphisms have been identified in the Tp53 gene from individuals of African descent and European descent. These amino acid changes are as follows (the p53 protein is composed of 393 amino acids).
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