Fig. 7: RTN3-mediated lipid accumulation in heart tissue from obese patients. | Cell Death & Differentiation

Fig. 7: RTN3-mediated lipid accumulation in heart tissue from obese patients.

From: Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis

Fig. 7

Quantitative analysis of BMI (a), E/A ratio (b), LVEF (c), LVFS (d), and cardiac output (e) in obese patients and NW individuals (n = 20 individuals each group); representative oil red staining images indicating intramyocardial lipid content (f) and quantitative analysis of positive area of oil red staining (g) (n = 3 individuals each group), scale bar = 20 μm. h Representative western blotting images and quantitative analysis of RTN3 protein level (n = 3 individuals each group); Representative immunohistochemical images indicating RTN3 protein level (i) and quantitative analysis of H-score of immunohistochemical staining images (j) (n = 3 individuals each group), scale bar = 30 μm; k Representative western blotting images of IP assay using different antibody to determine the interaction of RTN3 and FABP5. Data are expressed as Mean ± SEM. Differences are significant for *P < 0.05, **P < 0.01.

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