Fig. 4: The combined absence of ZMAT3, PUMA and p21 causes spontaneous tumour development in mice.
From: Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice
A Kaplan-Meier curves showing tumour-free survival of Puma−/−p21−/−Zmat3−/−, Puma−/−Zmat3−/− and p21−/−Zmat3−/− mice. Data from wt and Trp53−/− mice are included as controls. Log-rank (Mantel-Cox) test P values comparing to wt mice; Puma−/−p21−/−Zmat3−/− p = 0.003**; Puma−/−p21−/− p = 0.06; Puma−/−Zmat3−/− p = 0.26; ****p < 0.0001. B Representative H&E-stained sections of spleen, bone marrow (sternum) and thymus of sick Puma−/−p21−/−Zmat3−/− (#454,615) and Puma−/−Zmat3−/− (#471,624) mice, and an age-matched healthy wt (#953) mouse for comparison. Scale bar denotes 500 µm or 20 µm, respectively. N number of mice of a particular genotype analysed. C Model: ZMAT3 loss drives spontaneous tumour development in collaboration with additional loss of PUMA and p21.
