Fig. 1: Loss of functional p53 is a critical factor in promoting genomic instability and contributing to cancer development.
From: Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

The sequence and timing of the events in the development of genomic instability have a defined order. Schematic representation of order in genetic events proposed to accompany the transition from normal tissue to malignancy. Created with BioRender.com (Agreement number: IR26AKIJ23).