Fig. 2: Activation of p53 in response to stress signals initiates its transcriptional activity, leading to the activation of cellular protective pathways. | Cell Death & Differentiation

Fig. 2: Activation of p53 in response to stress signals initiates its transcriptional activity, leading to the activation of cellular protective pathways.

From: Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

Fig. 2

p53 binds to the DNA in a tetrameric configuration and promotes the transcription of a wide array of genes. Pictured are key p53 pathways and transcriptional targets regulated by p53 with a specific emphasis on p53-dependent DNA repair genes. BER (base excision repair), NER (nucleotide excision repair), MMR (mismatch repair), HR (homologous recombination), NHEJ (non-homologous end-joining), DDR (DNA damage repair) Created with BioRender.com (Agreement number: YM26AKJ2TU).

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