Fig. 4: Mutant p53 alters the epigenetic landscape of cancer cells via multiple mechanisms.
From: Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?
a The interaction between mutant p53 and ETS2 has been demonstrated to enhance the expression of epigenetic regulators, namely, MOZ, MLL1, and MLL2. The upregulation of these regulators is implicated in promoting tumor growth. b, c The interaction of mutant p53 with the SWI/SNF chromatin remodeling complex, involving HIF-1 or alternative unidentified transcriptional factors, induces the expression of genes that contribute to therapy resistance, microenvironment remodeling, and tumor progression. d Mutant p53 recruitment by BRD4 to the Csf-1 promoter, highly enriched in H3 Lysine 27 Acetylation, results in the induction of its expression, thereby promoting metastasis.
