Fig. 2: Mitophagy during apoptosis occurs independent of PINK1/Parkin mitophagy and STING-induced autophagy. | Cell Death & Differentiation

Fig. 2: Mitophagy during apoptosis occurs independent of PINK1/Parkin mitophagy and STING-induced autophagy.

From: Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy

Fig. 2

Flow cytometry ratio analysis of Mcl1−/− MEFs expressing mtKeima, lacking either Parkin, PINK1, or STING, and treated with DMSO, ABT-737 [1 µM] ± QVD-OPh [20 µM] for 8 h or 24 h. Data representation of mtKeima median ratio change, normalised to DMSO (A) Parkin+/+Mcl1CRISPR and Parkin−/−Mcl1CRISPR (B) Mcl1−/− and Pink1−/−Mcl1CRISPR. C Schematic representation of how mtDNA release may activate STING-induced autophagy. D Mcl1−/− and Sting−/−Mcl1CRISPR, data representation of mtKeima median ratio change, normalised to DMSO. Bars represent mean ± SEM, n = 3 independent experiments, paired data from the same experiment are represented by the same symbol shape.

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