Fig. 2: The role of PML in proliferation, migration, and invasion of ER+ breast cancer cells. | Cell Death & Differentiation

Fig. 2: The role of PML in proliferation, migration, and invasion of ER+ breast cancer cells.

From: The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer

Fig. 2

The effects of transient PML knockdown (A, D, F) and PML1 overexpression (B, E, G) on proliferation (A, B), colony formation (D, E), and invasion (F, G) of MCF-7 and ZR75-1 cells. The effects of PML1 overexpression on proliferation (B), colony formation (E), and invasion (G) of MCF-7 and ZR75-1 cells. C Exogenous PML1 rescues the proliferation defect of PML knockdown cells. H PML1 increases fulvestrant IC50. The data were analyzed using one-way ANOVA. PML1-OE experiments were performed with N = 8, while the rest had N = 3.

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