Fig. 7: A schematic model showing c-Myc O-GlcNAcylation regulates the TCA cycle and tumor growth in CRC.
From: The OGT–c-Myc–PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth
S415 O-GlcNAcylation represses the degradation of c-Myc. Thus, c-Myc O-GlcNAcylation facilitates the Warburg effect and results in colorectal cancer tumorigenesis.
